Upadacitinib: A Convenient and Effective Alternative Treatment for Spondyloarthritis

By Staff Writer

February 3, 2023

Treatment guidelines for adults with active non-radiographic axial spondyloarthritis recommend the use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Tumor Necrosis Factor-alpha (TNF-alpha) inhibitors. If these first-line treatments don’t work or aren’t suitable, doctors may consider secukinumab or ixekizumab (IL-17 inhibitors). Clinical trials show that upadacitinib, an oral Janus Kinase (JAK) inhibitor, can reduce symptoms and improve the quality of life in Spondyloarthritis (SpA) patients. This effectiveness rivals that of biologics. Clinicians use the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score and/or Visual Analogue Scale (VAS) score to measure this. A cost comparison shows that upadacitinib costs about the same and provides similar health benefits as secukinumab and ixekizumab.

The update suggests considering upadacitinib as an alternative to the National Institute for Health and Care Excellence (NICE) recommended Interleukin (IL)-17 inhibitors. This is especially important if conventional therapy doesn’t control the condition well enough or if TNF-alpha inhibitors aren’t suitable or effective.

Clinical and patient experts highlighted the convenience of upadacitinib over IL-17 inhibitors owing to its oral administration.

Reference url

Recent Posts

endometrial cancer mortality
      

Trends in Endometrial Cancer Mortality

💭 Are we doing enough to address ethnic disparities in endometrial cancer mortality?
A recent study highlights alarming trends in endometrial cancer mortality rates in South Africa, where rates have nearly doubled from 1999 to 2018, with significant variations among different ethnic groups. Understanding these disparities is crucial for developing targeted public health strategies to improve outcomes.

Look into the full article to explore the key insights and implications for healthcare policy and intervention strategies.

#SyenzaNews #globalhealth #healthcarepolicy

HIV cancer care integration
       

HIV Cancer Care Integration in Sub-Saharan Africa

🌍 How can integrating HIV care transform cancer treatment in Africa?

Healthcare providers in Malawi, South Africa, Uganda, and Zimbabwe are optimistic about merging HIV support with cancer treatment, despite facing challenges like workspace constraints and financial pressures. This integration is key for enhancing patient outcomes and efficiency in care delivery.

Look into the insights and barriers identified in this crucial discussion.

#SyenzaNews #ClinicalTrials #GlobalHealth #HealthcareInnovation

HPV vaccine uptake
        

Boosting HPV Vaccine Uptake Among Young People Post-Pandemic

💉 Are we doing enough to protect our youth against HPV-related cancers?

The UK Health Security Agency is calling on young people to seize the opportunity for HPV vaccination, especially those who missed out during the pandemic.

With increasing uptake rates among year 8 students, there’s still work to be done to reach pre-pandemic levels and ensure the effectiveness of the single-dose schedule introduced in September.

Jump into the article to see how these vaccinations can prevent cancer and the important roles we all play in promoting public health!

#SyenzaNews #HealthTech #HealthcareInnovation #CRO

When you partner with Syenza, it’s like a Nuclear Fusion.

Our expertise are combined with yours, and we contribute clinical expertise and advanced degrees in health policy, health economics, systems analysis, public finance, business, and project management. You’ll also feel our high-impact global and local perspectives with cultural intelligence.

SPEAK WITH US

CORRESPONDENCE ADDRESS

1950 W. Corporate Way, Suite 95478
Anaheim, CA 92801, USA

© 2025 Syenza™. All rights reserved.