
Bihormonal artificial pancreas reimbursement denied in the Netherlands
Zorginstituut Nederland has ruled that the Inreda AP stays out of the Dutch basic package. The DARE trial found no clinically relevant gain in glucose control or quality of life, serious adverse events were about three times more common, and half of the patients stopped using the device. #SyenzaNews #MedTech #MarketAccess #HealthEconomics
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News
The economic burden of obesity in Europe: up to 1.4% of GDP
New OHE research puts the economic burden of obesity in eight European countries at 0.7% to 1.4% of GDP. Germany carries the largest bill at EUR 55.2bn; the UK carries the largest productivity share at 58%. #SyenzaAI #SyenzaNews #MarketAccess #HealthEconomics #Obesity

News
AI Governance in HTA: Ethics, Autonomy and Accountability
Syenza’s webinar on AI governance in HTA drew 71% of participants who had not yet used AI in their work. The session covered the paper’s governance checklist, the in-house Navigator tool, and a live rapid HTA of rituximab in lupus. #SyenzaNews #HTA #AIinHealth #MarketAccess

News
Minimal Stimulation IVF Is Cheaper Per Cycle, but the Savings Case Is Unsettled
Minimal stimulation IVF lowers the cost of a cycle. A health economist and a US patient advocate told an IFFS webinar that the savings case, and the bill patients carry, are both unsettled. #SyenzaNews #IVF #MarketAccess #HealthEconomics

News
Sweden Reports Rise in Semaglutide Adverse Reactions
Sweden’s pharmaceutical injury insurance logged 33 semaglutide adverse reactions claims in the first eight months of 2026, up from 13 in all of 2025. More prescribing and more awareness explain the rise better than any new risk.
#SyenzaNews #pharmaceuticals #drugsafety #regulatoryaffairs

News
South Africa Approves Second Single Exit Price Adjustment for 2026
South Africa has set a second single exit price adjustment for 2026, lifting listed medicine prices by 2.88% from 1 October. #SyenzaNews #MarketAccess #Pharma

News
Roche’s Enicepatide Type 2 Diabetes Trial Meets HbA1c and Weight Goals
Roche’s dual GLP-1/GIP agonist enicepatide met both Phase II endpoints in type 2 diabetes, cutting HbA1c 2.65% and weight 15.5% at 48 weeks. #SyenzaNews #type2diabetes #GLP1 #obesity

News
COMP Recommends 12 EMA Orphan Drug Designations in July
COMP’s July 2026 sitting recommended 12 orphan drug designations, withdrew four, and sharpened the test for significant benefit against authorised therapies. #SyenzaNews #OrphanDrugs #MarketAccess #RareDiseases

News
European Pharmaceutical Investment Losing Ground, Nine Chairs Warn
Nine pharma chairs, from AstraZeneca to Sanofi, warn Europe is losing the pharmaceutical investment race to the US and China, and call on governments to treat medicines as strategic infrastructure. #SyenzaNews #pharmaceuticals #MarketAccess #drugdevelopment

News
SAHPRA Annual Report: Clean Audit and WHO ML3 Vaccine Milestone
SAHPRA reports a clean audit, WHO ML3 vaccine maturity, and ICH membership in its 2025/26 annual report, with R515.7 million in revenue and a R33.7 million surplus. #SyenzaNews #MarketAccess #SAHPRA

News
Responsible AI Regional Networks: The Missing Link for Low-Resource Health Systems
Regional networks anchored to local contexts are the missing link for responsible AI in low-resource health systems, a new npj Digital Medicine Perspective argues. #ResponsibleAI #DigitalHealth #GlobalHealth #HealthEquity
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