PhRMA’s Patient Access Investment: $500 Billion Commitment to Domestic Infrastructure and Care

By HEOR Staff Writer

September 30, 2025

Yesterday PhRMA announced steps to boosting patient access to treatments. The announcement showcases the U.S. biopharmaceutical industry’s initiative to enhance patient access and stimulate economic growth. The announcement outlines a remarkable $500 billion in new U.S. infrastructure spending. It also details expanded financial assistance programs benefiting 10 million Americans annually and the launch of a direct purchase website designed to simplify access to medications. These initiatives are framed as necessary responses to ongoing systemic insurance barriers and international price discrepancies. They also advocate for regulatory reforms essential to maintain American innovation and market competitiveness.

Unprecedented Economic Commitment and Patient Aid

A central theme in PhRMA’s announcement is the unprecedented pledge to invest $500 billion in U.S.-based manufacturing and infrastructure. This is projected to generate $1.2 trillion in downstream economic impact and create over 100,000 new jobs, including 25,000 positions in the biopharmaceutical sector. This substantial investment acts as a catalyst for domestic economic activity. It reinforces findings that investments by the pharmaceutical industry notably influence regional labor dynamics, supply chain efficacy, and demand for related services. PhRMA highlights that the economic ripple effect extends beyond direct job creation. It also stimulates local sectors including education, childcare, and various service industries.

Moreover, PhRMA’s expansion of patient financial assistance programs aims to reach 10 million Americans annually. This addresses gaps caused by what is described as a “broken health insurance system.” Results from recent surveys indicate significant barriers to medication access. These include increasing out-of-pocket costs and limited formulary options. These findings align with policy briefs that illustrate how cost-sharing requirements and drug exclusions can adversely impact patient adherence and health outcomes. PhRMA’s established support infrastructure plays a crucial role in effectively implementing these assistance programs across diverse patient populations. It features resources like the Medicine Assistance Tool (MAT.org).

Direct Purchase Initiatives and Transparency Push

The upcoming launch of AmericasMedicines.com in January 2026 represents a pivotal shift. It aims to increase transparency and enhance direct connections between manufacturers and consumers. This initiative is a strategic response to widespread concerns regarding Pharmacy Benefit Managers (PBMs) and other intermediaries. These intermediaries absorb significant rebates while maintaining high retail prices for patients. Industry analyses similarly identify PBMs and opaque supply chain practices as major contributors to misaligned incentives, diminished price transparency, and inflated consumer medicine costs. By adopting a transparent direct purchase model, PhRMA aligns with policy advocates who have called for reduced patient expenditures and increased employer involvement in prescription drug markets. This model is characterized by no hidden markups and simplified access.

A Comprehensive Approach to Health Economics and Patient Care

PhRMA’s multifaceted strategy signals the pharmaceutical sector’s commitment to fortifying the U.S. innovation base while tackling critical access barriers. This strategy encompasses substantial infrastructure investment, enhanced patient assistance programs, and increased marketplace transparency. For HEOR professionals, these developments present new data sources and potential experiments. They can investigate the impacts of direct manufacturer engagement, patient assistance mechanics, and infrastructure investments on health outcomes, affordability, and disparities in healthcare access.

As the market access landscape evolves, opportunities will arise to assess changes in pricing, supply chain efficiency, and patient satisfaction. This evolution may diminish PBM influence while welcoming consumer-friendly digital tools. The underlying regulatory context remains vital, particularly concerning price negotiation, international pricing standards, and insurance reform. Advancing these reforms alongside industry initiatives may effectively address ongoing challenges related to affordability and access.

In conclusion, the actions announced by PhRMA illustrate both the industry’s self-regulation and responsiveness to political pressures. They have significant implications for future research and policy dialogue surrounding market access, price transparency, and patient-centered care. The outcomes of these initiatives will be of great interest to HEOR professionals. They aim to understand and quantify shifts in spending, access, and healthcare system performance in the face of these transformative changes. For further insights into this pivotal commitment, you can explore the full details of PhRMA’s actions below.

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