Comprehensive Review of Methods to Assess Uncertainty in Health Economic Evaluations

By HEOR Staff Writer

March 22, 2023

As healthcare costs continue to rise, accurate cost-effectiveness estimates are crucial. However, estimating the costs and outcomes of different interventions is complicated by uncertainty.

In model-based health economic evaluations (HEEs), uncertainty can arise from limited data, methodological limitations, and variability in clinical outcomes.

A recent review identified 80 methods for identifying, analyzing, and communicating uncertainty in HEEs. Quantifying uncertainty wherever possible is crucial to ensure accurate and unbiased cost-effectiveness estimates, ultimately leading to optimal allocation of healthcare resources

Reference url

Recent Posts

global instability generic pharmaceutical sustainability
Global Instability Impacting Generic Pharmaceutical Sustainability in Portugal

By João L. Carapinha

July 8, 2026

Global instability impacting generic pharmaceutical sustainability has become a pressing challenge for Portugal, where rising international conflicts are undermining the economic viability of generic drug production. After 34 years of ensuring affordable access to essential treatments, these medi...
BFI healthcare procurement South Africa
BFI Healthcare Procurement South Africa Driving Infrastructure Advancements

By João L. Carapinha

July 8, 2026

South Africa’s healthcare system stands at a pivotal moment as BFI healthcare procurement accelerates the delivery of modern hospitals and clinics. The Department of Health is preparing 11 formal bids for the Budget Facility for Infrastructure (BFI), signalling a decisive shift from slow annual a...
omaveloxolone appropriate utilization consensus
Omaveloxolone Appropriate Utilization Consensus Framework for Friedreich Ataxia

By João L. Carapinha

July 8, 2026

The omaveloxolone appropriate utilization consensus delivers a tightly controlled framework for using Skyclarys in Friedreich’s ataxia, restricting initiation and discontinuation decisions to two specialized Dutch centers. By combining validated functional scales with strict safety thresholds and...