Advances in Colorectal Cancer Screening: Access and Cost

By Rene Pretorius

March 31, 2025

Summary

The article discusses advances in colorectal cancer screening . It focuses on a blood test called Shield and advancements in stool tests. The Shield test shows promise but is less effective than colonoscopies or FIT-DNA stool tests. It may help those hesitant about traditional screenings. However, its effectiveness in younger groups and long-term costs remain unclear.

Key Insights

  • Emerging Blood Tests: The Shield blood test finds 83% of colorectal cancer cases. Yet it detects only 13% of advanced polyps, with a 10% false-positive rate. It is not yet FDA-approved but could become more available if approved.
  • Stool Tests: FIT-DNA tests like Cologuard are more accurate. They detect 92-94% of colorectal cancer cases and 42-43% of advanced polyps, with fewer false positives.
  • Colonoscopies: These remain the gold standard, detecting 95% of cases. However, they are invasive and costly.

Background Context

Colorectal cancer is a leading cause of cancer death in the U.S. Effective screening is vital. Colonoscopies are accurate but often avoided due to discomfort and cost. Newer noninvasive tests aim to boost screening rates. The U.S. Preventive Services Task Force recommends regular screening, including stool tests and colonoscopies. Novel markers are being developed for better noninvasive tests.

Implications

Noninvasive tests like Shield could improve screening adherence by simplifying the process. However, if they replace colonoscopies, cancer rates and costs may rise due to their lower effectiveness. Cost-effectiveness and long-term outcomes need more study. This includes comparing frequent screening with less frequent but more thorough colonoscopies.

Also see original coverage of new approaches to colorectal cancer screening.

Reference url

Recent Posts

allopurinol Marfan syndrome orphan
       

Allopurinol Designated an Orphan Drug for Marfan Syndrome

🌟 What does the EMA’s orphan drug designation for allopurinol mean for those impacted by Marfan syndrome?

This groundbreaking move highlights a significant step forward in tackling rare diseases, offering hope to patients with limited treatment options. Allopurinol, traditionally used for gout, shows promise in addressing life-threatening aortic complications associated with Marfan syndrome, thanks to its antioxidant properties.

Dive into the implications of this development for healthcare innovation, patient access, and the future of rare disease treatment!

#SyenzaNews #HealthEconomics #Innovation #MarketAccess

marstacimab hemophilia B
                

NICE’s Approval of Marstacimab for Hemophilia B: Transforming Treatment Landscapes and Economic Implications

💡 Are we witnessing a paradigm shift in hemophilia treatment?

The recent recommendation from NICE for marstacimab as a novel therapy for severe hemophilia B is a game-changer. With its ability to provide effective prophylaxis while potentially lowering treatment costs, this could reshape patient care and health economics in this space.

Dive into the implications this has for patients and healthcare providers, and why marstacimab’s approval could be a pivotal moment for hemophilia management.

Explore the full article for deeper insights!

#SyenzaNews #HealthEconomics #HealthcareInnovation #MarketAccess

HPV-related cancer trends
    

HPV-Related Cancer Trends in South Africa 2011-2021

🌍 Are we witnessing a rise in HPV-related cancer in South Africa?

A recent analysis of data from the South African National Cancer Registry highlights concerning trends: while cervical cancer rates are declining, there’s an alarming rise in non-cervical anogenital cancers. This underscores the urgent need for enhanced cancer prevention and access to efficient healthcare services in the country.

Dive into the findings and explore the implications for health systems and policies.

#SyenzaNews #HealthEconomics #HealthcareInnovation #GlobalHealth

When you partner with Syenza, it’s like a Nuclear Fusion.

Our expertise are combined with yours, and we contribute clinical expertise and advanced degrees in health policy, health economics, systems analysis, public finance, business, and project management. You’ll also feel our high-impact global and local perspectives with cultural intelligence.

SPEAK WITH US

CORRESPONDENCE ADDRESS

1950 W. Corporate Way, Suite 95478
Anaheim, CA 92801, USA

© 2025 Syenza™. All rights reserved.