Tezepelumab as an Add-on Maintenance Treatment for Severe Asthma: Recommendations and Clinical/Economic Impact.

By Staff Writer

April 25, 2023

Tezepelumab as an add-on maintenance treatment is recommended as an option for severe asthma in people 12 years and over, when treatment with high-dose inhaled corticosteroids plus another maintenance treatment has failed.

It is recommended only if people:

  • Have had 3 or more exacerbations in the previous year, or
  • Are having maintenance oral corticosteroids.

Tezepelumab should be discontinued if the rate of severe asthma exacerbations, or the maintenance oral corticosteroid dose, have not been reduced by at least 50% at 12 months.

Clinical impact:
Clinical trial results show that tezepelumab, when added to usual treatment, reduces exacerbations and the dose of oral corticosteroids needed, compared with placebo. An indirect comparison of tezepelumab with other biological treatments suggests similar clinical effectiveness, but this is uncertain.

Economic impact:
The cost-effectiveness estimates show that Tezepelumab as an add-on maintenance therapy is cost effective compared with standard care and other biological (benralizumab, mepolizumab, reslizumab, dupilumab and omalizumab) treatments.

Reference url

Recent Posts

Keytruda biosimilar collaboration
     

What are the Plans and Implications for Keytruda´s Biosimilar

🌍 Keytruda, Merck’s $29.5B oncology juggernaut, faces a patent cliff by 2028. Who’s poised to disrupt its next chapter with a biosimilar?

Alvotech and Dr. Reddy’s Laboratories are making a bold play, partnering to co-develop and commercialize a pembrolizumab biosimilar. Leveraging Alvotech’s R&D prowess and Dr. Reddy’s global manufacturing and market reach, this alliance aims to capture share in the post-patent immuno-oncology market while driving down costs.

Dive into the full article to unpack how this strategic move could reshape access and competition in oncology.

#SyenzaNews #oncology #biosimilars #pharma #innovation

transparency in peer review
       

The Case for Transparency in Peer Review: Enhancing Scientific Integrity and Trust

🔍 Are we overlooking the importance of transparency in peer review?

In a recent article from the BMJ, the debate surrounding the necessity of transparency in scientific research heats up. While some argue it adds unnecessary burdens, this perspective misses the critical role transparency plays in building trust and ensuring reproducibility in our findings.

Dive into how embracing openness not only enhances scientific integrity but also shapes effective health policies. Don’t miss the chance to elevate your understanding of transparency in research!

#SyenzaNews #HealthEconomics #HealthcarePolicy #Innovation

access to medicines
         

Quantifying EU Medicine Access Challenges

🔍 Are we creating a healthcare system that truly works for everyone?

Recent findings from EFPIA shed light on alarming inequities in access to medicines across Europe, showing that only 46% of approved drugs are available to patients this year. With significant delays affecting smaller markets and critical cancer treatments, this article explores the systemic barriers at play and innovative solutions proposed to ensure fair access.

Dive into the full article to uncover how we can collectively shape a more equitable healthcare landscape.

#SyenzaNews #healthcare #MarketAccess

When you partner with Syenza, it’s like a Nuclear Fusion.

Our expertise are combined with yours, and we contribute clinical expertise and advanced degrees in health policy, health economics, systems analysis, public finance, business, and project management. You’ll also feel our high-impact global and local perspectives with cultural intelligence.

SPEAK WITH US

CORRESPONDENCE ADDRESS

1950 W. Corporate Way, Suite 95478
Anaheim, CA 92801, USA

© 2025 Syenza™. All rights reserved.