NICE’s Preparations for Evaluating New Alzheimer’s Treatments

By Danélia Botes

December 27, 2023

The Advent of Disease-Modifying Dementia Treatments (DMDTs)

Recent years have seen significant strides in our understanding of dementia, particularly Alzheimer’s disease. These advancements have led to the development of Disease-Modifying Dementia Treatments (DMDTs). These treatments aim to alter the course of disease progression and reduce its severe impact. Currently, the UK has not licensed any DMDTs, but several are undergoing various stages of development and approval. The National Institute for Health and Care Excellence (NICE) will be evaluating new Alzheimer’s treatments, namely, lecanemab and donanemab, next year. 

Preparing for the Evaluating New Alzheimer’s Treatments

In preparation for the evaluation of these innovative treatments, NICE, in collaboration with the NHS and patients, has initiated work to identify potential issues that may arise during planned and future evaluations. This work is being carried out by NICE’s Health Technology Assessment Innovation Laboratory (HTA Lab) and is based on current knowledge, publicly available evidence, and in-depth discussions with researchers, patient groups, and NHS colleagues.

Key Issues to Consider in the Appraisal Process

The report highlights several issues that require attention in a comprehensive appraisal process. One issue is the uncertainty surrounding the number of people with mild cognitive impairment. Another concern is the present need for invasive tests to determine eligibility for new treatments. Lastly, there’s a critical lack of data on the long-term effectiveness of DMDTs currently published. Extensive assumptions will be required to extrapolate results from current research trials to infer the lifetime benefit of DMDTs in terms of quality and length of life.

Economic Modelling Considerations and the Future of Dementia Treatment

Economic modelling considerations also come into play. DMDTs are expected to be administered by intravenous infusions in hospitals, and the economic models will need to include these additional costs. Despite these challenges, NICE’s methods and processes for technology appraisal continue to be suitable for assessing these innovative new treatments.

The development of disease-modifying treatments for dementia represents a long-awaited change in the management of a condition associated with a considerable burden of illness. The UK is at the forefront of this research, and these new treatments represent potentially significant advancements in the field.

Reference url

Recent Posts

Cost and clinical impact of MIS-C

Understanding the Cost and Clinical Impact of Multisystem Inflammatory Syndrome in Children (MIS-C)

🔍 Discovering the Economic Impact of Multisystem Inflammatory Syndrome in Children (MIS-C) 🏥💰

Understanding the cost and clinical impact of MIS-C during COVID-19 is crucial for healthcare providers and policymakers. Learn about treatment costs, patient outcomes, and key statistics related with MIS-C.

🌟#Healthcare #MIS-C #COVID19 #Pediatrics #HealthEconomics #MedicalResearch #HealthcareResearch #MedicalEconomics 📊

Let’s navigate the intersection of healthcare and economics together! 💼 #HealthcareInsights #EconomicAnalysis 🧠


Striking the Balance: Optimising Hepatitis B Treatment Strategies in The Gambia

Hepatitis B continues to pose a significant public health challenge, but the World Health Organization continues to work towards achieving their ambition of eliminating HBV as a public health problem by 2030.

One strategy is the Treat All approach, which sounds promising – however, in low-resource settings implementing promising strategies becomes more complex. This study explores striking the balance between promising strategies and getting people the treatment they need.

Learn more about innovative HBV treatment approaches and their impact on global health. Stay informed and join the conversation! 💡🔬 #HealthcareInnovation #HBVResearch

cost effectiveness multiple sclerosis

Cost-Utility and Cost-Effectiveness of Disease-Modifying Drugs for Relapsing-Remitting Multiple Sclerosis

Exploring the Cost-Utility of MS Treatments: A Comprehensive Review 🧠💼 Dive into the latest findings on the cost-effectiveness of Disease-Modifying Drugs for Multiple Sclerosis. Discover key insights and recommendations for optimizing treatment strategies. #MSresearch #HealthcareEconomics #Neurology #HealthTech 📊🔬

When you partner with Syenza, it’s like a Nuclear Fusion.

Our expertise are combined with yours, and we contribute clinical expertise and advanced degrees in health policy, health economics, systems analysis, public finance, business, and project management. You’ll also feel our high-impact global and local perspectives with cultural intelligence.



1950 W. Corporate Way, Suite 95478
Anaheim, CA 92801, USA



© 2024 Syenza™. All rights reserved.