Large Language Models in Evidence-Based Medicine
Large Language Models in Evidence-Based Medicine

By João L. Carapinha

July 3, 2026

Large language models deliver rapid synthesis of medical literature, but according to research on fast information and slow evidence, they cannot independently generate validated evidence for clinical decisions. These tools sit at a...
African Pharmacogenomic Integration Enhancing Essential Medicine Prescribing in Africa
African Pharmacogenomic Integration Enhancing Essential Medicine Prescribing in Africa
African Pharmacogenomic Integration has become an urgent policy priority, with evidence showing that more than 10 percent of essential medicines across Africa require genetically guided prescribing to prevent harm and improve outcomes in diverse populations. Current dosage guidelines for HIV, ...
Pharmaceutical Manufacturing Affordability as a Key to South Africa’s Local Production Goals
Pharmaceutical Manufacturing Affordability as a Key to South Africa’s Local Production Goals
Pharmaceutical manufacturing affordability remains the decisive factor in South Africa’s efforts to build domestic capacity for essential medicines and vaccines. Government, industry and research leaders who met at the TIPS Development Dialogue on 17 June made clear that economic barriers to acce...
Catalysts Driving Portugal Biotech Growth in Europe
Catalysts Driving Portugal Biotech Growth in Europe

By João L. Carapinha

July 2, 2026

Portugal Biotech Growth is reshaping the country’s standing in European life sciences, delivering a compact yet high-potential ecosystem anchored by world-class universities in Porto and Coimbra, innovation parks, and forward-looking industrial policy. Once overshadowed by larger neighbours, Port...
Shingles Vaccine Affordability and Its Impact on Public Health in South Africa
Shingles Vaccine Affordability and Its Impact on Public Health in South Africa
Shingles vaccine affordability remains a pressing concern as the recombinant zoster vaccine launches in South Africa. This vaccine delivers substantially higher efficacy and longer protection against herpes zoster and post-herpetic neuralgia than the live attenuated version withdrawn in 2024, yet...
Widespread Barriers to Health Innovation Access in Portugal
Widespread Barriers to Health Innovation Access in Portugal
Health innovation access in Portugal is widely viewed as inadequate, with 80% of patient associations rating it as reasonable or poor. Only 14% say most relevant innovations reach patients without significant restrictions, according to a Medjournal.pt investigation. The gaps are most acute in ...
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Large Language Models in Evidence-Based Medicine

Global Updates

Large Language Models in Evidence-Based Medicine

By João L. Carapinha

July 3, 2026

Large language models deliver rapid synthesis of medical literature, but according to research on fast information and slow evidence, they cannot independently generate validated evidence for clinical decisions. These tools sit at a...
Retracted Trial Publication Undermines Support for Avacopan in AAV Treatment

Global Updates

Retracted Trial Publication Undermines Support for Avacopan in AAV Treatment

By João L. Carapinha

July 1, 2026

The Retracted Trial Publication of the ADVOCATE study has eliminated the central evidence that supported approval of Tavneos (avacopan) for severe active anti-neutrophil cytoplasmic autoantibody-associated vasculitis (AAV). At the request of two lead academic authors, the
Advancing Regulatory Validation Taletrectinib for Enhanced NSCLC Treatment

Global Updates

Advancing Regulatory Validation Taletrectinib for Enhanced NSCLC Treatment

By João L. Carapinha

June 30, 2026

The MHRA’s validation of Nuvation Bio’s marketing authorisation application marks an important regulatory validation taletrectinib for adults with advanced ROS1-positive non-small cell lung cancer. This milestone, achieved via the International Recognition Procedure in parallel with EMA review, f...
Global Impact of Portuguese Biotech Innovation

Global Updates

Global Impact of Portuguese Biotech Innovation
Portuguese Biotech Innovation has matured into a compelling global force, with Solfarcos marking a decade of translating University of Minho research into commercial technologies that span cosmetics and pharmaceuticals. The Braga-based spin-off has built a unified platform of peptides and protein...

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